Anti-Inflammatory Effect of Cudrania tricuspidata Extract and Stewartia koreana Extract Mixture in a Collagen-Induced Arthritis Mouse Model

Cudrania tricuspidata extracts (CTE) and Stewartia koreana (SKE) are viable drugs for managing inflammation. We investigated the nitric oxide levels of CTE a mixture CTE/SKE (CTE mix) against lipopolysaccharide-induced RAW264.7 cells. In addition, we administered mix to mice with collagen-induced arthritis confirm an anti-inflammatory effect rheumatoid arthritis. analyzed symptoms by oral administration using CIA-induced animal model inhibitory activity NO production in vitro experiments. Both decreased levels, 2:1 ratio was most effective vivo among varying ratios tested. The spleen size increased about 2.1 times, lymph node 2.5 times relative compared vehicle group. blood biochemical analyses, tumor necrosis factor–α three interleukin-1β interleukin-6 were reduced eight PRG4 expression suggest that superior alone has potential as treatment patients